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Biological Products. Investigational Cellular Therapies. International Competent Authorities. The clinical significance of the potassium load depends on the speed and volume of the transfusion, as well as the age of the blood. Blood for intrauterine and exchange transfusion should be used within 24 hours of irradiation. The following tool provides health professionals with guidance on the use of irradiated cellular components. This guidance, which is based on current national guidelines, may not be appropriate in all patient situations, and individual circumstances or evolving best clinical practice may dictate an alternative approach.
Purine analogues which can cause immune suppression include fludarabine, deoxycoformycin pentostatin , chlorodeoxyadenosine cladribine , clofarabine and bendamustine. Patients should receive irradiated cellular components during treatment and for a least 1 year following treatment.
Patients with active chronic transplant-related GVHD should continue to receive irradiated cellular blood components. Consideration should be given to transfusing irradiated cellular components to patients with B and T cell NHL.
No definitive recommendations can be made, therefore consideration should be given to transfusing irradiated cellular components to patients. Routine use of irradiated cellular components is not indicated unless other risk factors are present including autologous HSCT and the use of nucleoside analogues. No definitive recommendations can be made, but consideration should be given to patients with aplastic anaemia who are receiving immunosuppressive therapy.
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